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TRIM56 (DGR19439) Rabbit mAb
db13024
Datasheet
- Background E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).
- Immunogen A synthetic peptide of human TRIM56
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Gene ID
81844
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Swiss Prot
Q9BRZ2
- Synonyms RNF109
- Reactivity Human
- Application WB, IHC-P, ICC/IF, FC
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Recommended dilution
WB: 1:2000-1:20000
IHC-P: 1:200-1:1000
ICC/IF: 1:50-1:100
FC: 1:20-1:50 - Calculated MW 82 kDa
- Observed MW 82 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR19439
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of TRIM56 in Hela cell lysates using TRIM56 antibody(1:1000 diluted). -
Immunofluorescent analysis of HeLa cells using db13024 antibody (green), and DAPI (blue).
订购信息
- Package Price (RMB)
- 10μL 398
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
