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smooth muscle Myosin heavy chain 11 (DGR15261) Rabbit mAb
db15098
Datasheet
- Background The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- Immunogen A synthetic peptide of human smooth muscle Myosin heavy chain 11
-
Gene ID
4629
-
Swiss Prot
P35749
- Synonyms AAT4; FAA4; SMHC; SMMHC
- Reactivity Human
- Application WB, IHC-P, ICC/IF, FC
-
Recommended dilution
WB: 1:1000-1:5000
IHC-P: 1:200-1:1000
ICC/IF: 1:50
FC: 1:20 - Calculated MW 227 kDa
- Observed MW 255 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR15261
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
- Package Price (RMB)
- 10μL 398
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
