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Ataxin-2 (DGR35777) Rabbit mAb
db16581
Datasheet
- Background This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticulum and plasma membrane, is involved in endocytosis, and modulates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
- Immunogen Recombinant protein of human Ataxin-2
-
Gene ID
6311
-
Swiss Prot
Q99700
- Synonyms ATX2; SCA2; TNRC13; ATXN2
- Reactivity Human, Mouse, Rat
- Application WB, IHC-P, ICC/IF, FC
-
Recommended dilution
WB: 1:1000
IHC-P: 1:200-1:1000
ICC/IF: 1:50
FC: 1:200-1:500 - Calculated MW 140 kDa
- Observed MW 150 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR35777
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
- Package Price (RMB)
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
