Proteasome Activator Subunit 4 Rabbit pAb - diagbio | 戴格生物

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Proteasome Activator Subunit 4 Rabbit pAb

db5121

Datasheet

Product Name : Proteasome Activator Subunit 4 Rabbit pAb

Cat.No.: db5121

Synonyms : PA200

Application : WB, IHC, ICC/IF, FC

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis.
Immunogen A synthetic peptide of human Proteasome Activator Subunit 4
Gene ID 23198
Swiss Prot Q14997
Synonyms PA200
Reactivity Human, Mouse, Rat
Application WB, IHC, ICC/IF, FC
Recommended dilution WB: 1:1000
IHC: 1:20
ICC/IF: 1:20
FC: 1:20
Calculated MW 211 kDa
Observed MW 211 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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