Recombinant Human MERTK / Mer Protein (His & Fc tag) - diagbio

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Recombinant Human MERTK / Mer Protein (His & Fc tag)

db58588

Datasheet

Product Name : Recombinant Human MERTK / Mer Protein (His & Fc tag)

Cat.No.: db58588

Synonyms : c-Eyk;c-mer;MER;RP38;Tyro12

Application : Positive Control, Immunogen, SDS-PAGE, WB

Tag : C-His & Fc

Expression host : HEK293 Cells

Species : Human

Background Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment
Gene ID 10461
Swiss Prot Q12866
Synonyms c-Eyk;c-mer;MER;RP38;Tyro12
Application Positive Control, Immunogen, SDS-PAGE, WB
Molecular Weight 80 kDa
Species Human
Expression Host HEK293 Cells
Purity >85% as determined by SDS-PAGE.
Seq Met 1-Ala 499
Tag C-His & Fc
Formulation Freeze-dried powder
Storage/Stability Store at 2-8℃ for one month. Aliquot and store at -80℃ for 12 months. Avoid repeated freeze/thaw cycles.

15% SDS PAGE(reduced) analysis of Recombinant Human MERTK / Mer Protein (His & Fc tag)

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