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LYRIC (2E4) Mouse mAb
db6403
Datasheet
- Background Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.
- Immunogen Purified recombinant fragment of human Metadherin expressed in E. Coli
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Gene ID
92140
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Swiss Prot
Q86UE4
- Synonyms 3D3; AEG1; LYRIC; MTDH
- Reactivity Human
- Application WB, IHC-P, FC
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Recommended dilution
WB: 1:500-1:1000
IHC: 1:50-1:100
FC: 1:50-1:100 - Calculated MW 64 kDa
- Observed MW 64 kDa
- Host species Mouse
- Clonality Monoclonal
- Clonality No. 2E4-D8-D11
- Isotype IgG1
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in PBS, 50% Glycerol(pH 7.3), 0.02% sodium azide and 0.5% BSA . Stable for 12 months from date of receipt.
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Western blot analysis of Lyric/Metadherin in Jurkat, A549, MCF-7 and Hela lysates using Lyric/Metadherin antibody. -
Flow cytometry analysis of Hela cells stained with Metadherin antibody(green) and negative control(purple). -
Immunohistochemistry analysis of paraffin-embedded Human Liver tissues using Metadherin antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
订购信息
- Package Price (RMB)
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
