TRIM56 Rabbit pAb - diagbio | 戴格生物

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TRIM56 Rabbit pAb

db8328

Datasheet

Product Name : TRIM56 Rabbit pAb

Cat.No.: db8328

Synonyms : RNF109

Application : WB, IHC, ICC/IF, FC

Reactivity : Human

Host species : Rabbit

Background E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).
Immunogen A synthetic peptide of human TRIM56
Gene ID 81844
Swiss Prot Q9BRZ2
Synonyms RNF109
Reactivity Human
Application WB, IHC, ICC/IF, FC
Recommended dilution WB: 1:2000-1:10000
IHC: 1:200-1:1000
ICC/IF: 1:50-1:100
FC: 1:20
Calculated MW 82 kDa
Observed MW 82 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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