ROCK1 (DGR12762) Rabbit mAb - diagbio | 戴格生物

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Recombinant DGRmAb^®

ROCK1 (DGR12762) Rabbit mAb

db11120

Datasheet

Product Name : ROCK1 (DGR12762) Rabbit mAb

Cat.No.: db11120

Synonyms : ROCK-I; P160ROCK

Application : WB, IHC-P, ICC/IF, FC, IP

Reactivity : Human,Mouse,Rat

Host species : Rabbit

Background This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
Immunogen A synthetic peptide of human ROCK1
Gene ID 6093
Swiss Prot Q13464
Synonyms ROCK-I; P160ROCK
Reactivity Human,Mouse,Rat
Application WB, IHC-P, ICC/IF, FC, IP
Recommended dilution WB: 1:1000-1:5000
IHC-P: 1:50-1:200
ICC/IF: 1:50-1:500
FC: 1:200-1:1000
IP: 1:50
Calculated MW 158 kDa
Observed MW 158 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR12762
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of ROCK1 in K562,C6 cell lysates using ROCK1 antibody (1:1000 diluted).
Western blot analysis of extracts from RAW264.7 cells using db11120 at 1:1000.

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