FADD Recombinant Rabbit mAb - diagbio | 戴格生物

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FADD Recombinant Rabbit mAb

db11195

Product Name : FADD Recombinant Rabbit mAb

Cat.No.: db11195

Synonyms : GIG3; MORT1

Application : WB, IHC, ICC/IF, FC, IP

Reactivity : Human

Host species : Rabbit

Background The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Immunogen A synthetic peptide of human FADD
Gene ID 8772
Swiss Prot Q13158
Synonyms GIG3; MORT1
Reactivity Human
Application WB, IHC, ICC/IF, FC, IP
Recommended dilution WB: 1:1000-1:5000
IHC: 1:20-1:100
ICC/IF: 1:20-1:50
FC: 1:20
IP: 1:20-1:50
Calculated MW 23 kDa
Observed MW 28 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of FADD in Rat Brain,3T3 cell lysates using FADD antibody(1:1000 diluted).

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