XIAP Recombinant Rabbit mAb - diagbio | 戴格生物

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XIAP Recombinant Rabbit mAb

db11787

Product Name : XIAP Recombinant Rabbit mAb

Cat.No.: db11787

Synonyms : API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3

Application : WB

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
Immunogen Recombinant protein of human XIAP
Gene ID 331
Swiss Prot Q60989
Synonyms API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3
Reactivity Human, Mouse, Rat
Application WB
Recommended dilution WB: 1:1000
Calculated MW 57 kDa
Observed MW 53 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of XIAP in K562,Rat Brain,3T3 cell lysates using XIAP antibody(1:1000 diluted).

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