Presenilin 1 Recombinant Rabbit mAb - diagbio | 戴格生物

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Presenilin 1 Recombinant Rabbit mAb

db13175

Product Name : Presenilin 1 Recombinant Rabbit mAb

Cat.No.: db13175

Synonyms : AD3; FAD; PS1; PS-1; S182

Application : WB, IHC, ICC/IF, FC, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
Immunogen A synthetic peptide of human Presenilin 1
Gene ID 5663
Swiss Prot P49768
Synonyms AD3; FAD; PS1; PS-1; S182
Reactivity Human, Mouse, Rat
Application WB, IHC, ICC/IF, FC, IP
Recommended dilution WB: 1:1000-1:5000
IHC: 1:20
ICC/IF: 1:20-1:50
FC: 1:20
IP: 1:20
Calculated MW 53 kDa
Observed MW 20 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot detection of Presenilin 1/PS-1 in Hela,C6,Jurkat cell lysates using Presenilin 1/PS-1 antibody(1:500 diluted).

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