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Presenilin 1 (DGR12409) Rabbit mAb (PBS Only)
db13175-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
- Immunogen A synthetic peptide of human Presenilin 1
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Gene ID
5663
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Swiss Prot
P49768
- Synonyms AD3; FAD; PS1; PS-1; S182
- Reactivity Human,Mouse,Rat
- Application WB, IHC-P
- Calculated MW 53 kDa
- Observed MW 20 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR12409
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/mL
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot detection of Presenilin 1/PS-1 in Hela,C6,Jurkat cell lysates using Presenilin 1/PS-1 antibody(1:500 diluted).
订购信息
- Package Price (RMB)
- 100μg 7858
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
