Phospho-MLKL (Ser345) (DGR15309) Rabbit mAb - diagbio | 戴格生物

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Recombinant DGRmAb^®

Phospho-MLKL (Ser345) (DGR15309) Rabbit mAb

db13947

Datasheet

Product Name : Phospho-MLKL (Ser345) (DGR15309) Rabbit mAb

Cat.No.: db13947

Synonyms : 9130019I15Rik

Application : WB, IP

Reactivity : Mouse

Host species : Rabbit

Background This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser345 of mouse MLKL
Gene ID 74568
Swiss Prot Q9D2Y4
Synonyms 9130019I15Rik
Reactivity Mouse
Application WB, IP
Recommended dilution WB: 1:1000
IP: 1:100-1:200
Calculated MW 54 kDa
Observed MW 54 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR15309
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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