您当前的位置：
Met (c-Met) (DGR12166) Rabbit mAb
db15811
Datasheet
- Background This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
- Immunogen Recombinant protein of human Met (c-Met)
-
Gene ID
4233
-
Swiss Prot
P08581
- Synonyms HGFR; AUTS9; RCCP2; c-Met; DFNB97
- Reactivity Human
- Application WB, IHC-P, ICC/IF, FC
-
Recommended dilution
WB: 1:1000
IHC-P: 1:200-1:2000
ICC/IF: 1:500-1:1000
FC: 1:200-1:500 - Calculated MW 156 kDa
- Observed MW 170,140 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR12166
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
×
![]()
-
Immunofluorescence analysis of HeLa cells labelling Met (c-Met) with db15811.
The cells were fixed with 4% PFA (10min, RT) followed by treatment with 0.1% Triton X-100 (10min, RT), and blocked in 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween 20 for 1h. The cells were then incubate with db15811 (1:1000) at room temprature for 1h, followed by a further incubation at room temperature for 45min with Goat Anti Rabbit lgG (H+L)-AF488 (db10005, shown in green). Nuclear DNA was labeled in blue with DAPI.
Control: Secondary antibody only.
订购信息
- Package Price (RMB)
- 10μL 398
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
