Fas (4C3) Mouse mAb - diagbio | 戴格生物

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Fas (4C3) Mouse mAb

db6064

Product Name : Fas (4C3) Mouse mAb

Cat.No.: db6064

Synonyms : FAS; ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6

Application : WB

Reactivity : Human

Host species : Mouse

Background Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
Immunogen Purified recombinant human FAS (C-terminus) protein fragments expressed in E.coli
Gene ID 355
Swiss Prot P25445
Synonyms FAS; ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6
Reactivity Human
Application WB
Recommended dilution WB: 1:500-1:1000
Calculated MW 38 kDa
Observed MW 45 kDa
Host species Mouse
Clonality Monoclonal
Clonality No. 4C3-G7-B7-H5
Isotype IgG1
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Stable for 12 months from date of receipt.

Western blot analysis of FAS(Cterminus) in Jurkat lysates using FAS(Cterminus) antibody.

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