STAT3 (4C8) Mouse mAb - diagbio | 戴格生物

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STAT3 (4C8) Mouse mAb

db6208

Product Name : STAT3 (4C8) Mouse mAb

Cat.No.: db6208

Synonyms : STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor

Application : WB

Reactivity : Human, Mouse, Rat, Monkey, Hamster

Host species : Mouse

Background Signal transducer and transcription activator that mediates cellular responses to interleukins,KITLG/SCF and other growth factors.May mediate cellular responses to activated FGFR1,FGFR2,FGFR3 and FGFR4.Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes.Activated by IL31 through IL31RA.Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity.Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G by similarity.
Immunogen Purified recombinant human STAT3 protein fragments expressed in E.coli
Gene ID 6774
Swiss Prot P40763
Synonyms STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor
Reactivity Human, Mouse, Rat, Monkey, Hamster
Application WB
Recommended dilution WB: 1:500-1:1000
Calculated MW 88 kDa
Observed MW 88 kDa
Host species Mouse
Clonality Monoclonal
Clonality No. 4C8-1C9-H8
Isotype IgG1
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Stable for 12 months from date of receipt.

Western blot analysis of STAT3 in CHO-K1, C6, 3T3, K562, CEM, Jurkat, Hela, MCF-7, COS7, 293T, A431 and A549 lysates using STAT3 antibody.

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