beta Catenin (5D6) Mouse mAb - diagbio | 戴格生物

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beta Catenin (5D6) Mouse mAb

db6360

Product Name : beta Catenin (5D6) Mouse mAb

Cat.No.: db6360

Synonyms : EVR7; CTNNB; MRD19; armadillo;CTNNB1

Application : WB

Reactivity : Human, Mouse, Rat

Host species : Mouse

Background Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Immunogen Purified recombinant human β-Catenin protein fragments expressed in E.coli
Gene ID 1499
Swiss Prot P35222
Synonyms EVR7; CTNNB; MRD19; armadillo;CTNNB1
Reactivity Human, Mouse, Rat
Application WB
Recommended dilution WB: 1:1000
Calculated MW 85 kDa
Observed MW 92 kDa
Host species Mouse
Clonality Monoclonal
Clonality No. 5D6-D5-E9
Isotype IgG1
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Stable for 12 months from date of receipt.

Western blot analysis of βCatenin in HCT116, C6 and 3T3 lysates using βCatenin antibody.

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