beta Catenin (5D6) Mouse mAb (PBS Only) - diagbio | 戴格生物

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beta Catenin (5D6) Mouse mAb (PBS Only)

db6360-PBS

Datasheet

Product Name : beta Catenin (5D6) Mouse mAb (PBS Only)

Cat.No.: db6360-PBS

Synonyms : EVR7; CTNNB; MRD19; armadillo;CTNNB1

Application：

Reactivity : Human, Mouse, Rat

Host species : Mouse

Un-conjugated PBS Only

Background Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Immunogen Purified recombinant human β-Catenin protein fragments expressed in E.coli
Gene ID 1499
Swiss Prot P35222
Synonyms EVR7; CTNNB; MRD19; armadillo;CTNNB1
Reactivity Human, Mouse, Rat
Application WB
Calculated MW 85 kDa
Observed MW 92 kDa
Host species Mouse
Clonality Monoclonal
Clonality No. 5D6-D5-E9
Isotype IgG1
Purity Affinity Purification
Conjugation Un-conjugated
Concentration 1 mg/mL
Formulation PBS Only
Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.

Western blot analysis of βCatenin in HCT116, C6 and 3T3 lysates using βCatenin antibody.

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