Product Name : Phospho-Presenilin 2 (Ser330) (DGR12408) Rabbit mAb (PBS Only)
Cat.No.: db11029-PBS
Synonyms : AD4; PS2; AD3L; STM2; CMD1V
Reactivity : Human, Mouse, Rat
Host species : Rabbit
Conjugation/Formulation：PBS Only
- Background Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
- Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser330 of human Presenilin 2
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Gene ID
5664
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Swiss Prot
P49810
- Synonyms AD4; PS2; AD3L; STM2; CMD1V
- Reactivity Human,Mouse,Rat
- Application WB
- Calculated MW 50 kDa
- Observed MW 23 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR12408
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/mL
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot detection of Phospho-Presenilin 2 (Ser330) in K562,C6,3T3,Hela cell lysates using Phospho-Presenilin 2 (Ser330) antibody(1:1000 diluted).
- Package Price (RMB)
- 100μg 5798
- 货期：现货
