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Conjugation/Formulation：Un-conjugated
- Background The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]
- Immunogen A synthetic peptide of human MLH1
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Gene ID
4292
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Swiss Prot
P40692
- Synonyms FCC2; COCA2; HNPCC; hMLH1; HNPCC2
- Reactivity Human, Mouse, Rat
- Application WB, IHC, ICC/IF, FC, IP
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Recommended dilution
WB: 1:2000
IHC: 1:50
ICC/IF: 1:50
FC: 1:20
IP: 1:20 - Calculated MW 85 kDa
- Observed MW 85 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR11983
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of MLH1 in K562,C6,3T3,Hela cell lysates using MLH1 antibody(1:1000 diluted). -
Immunofluorescent analysis of HeLa cells using db11226 antibody (green), and DAPI (blue).
订购信息
- Package Price (RMB)
- 10μL 398
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
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For research use only. Not intended for diagnostic.
