IDH1 (DGR15229) Rabbit mAb (PBS Only)
Product Name :
IDH1 (DGR15229) Rabbit mAb (PBS Only)
Cat.No.:
db11338-PBS
Synonyms :
IDH; IDP; IDCD; IDPC; PICD; HEL-216; HEL-S-26
Reactivity :
Human, Mouse, Rat
Host species :
Rabbit
Conjugation/Formulation：PBS Only
-
Background
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
-
Immunogen
A synthetic peptide of human IDH1
-
Gene ID
3417
15926
24479
-
Swiss Prot
O75874
O88844
P41562
-
Synonyms
IDH; IDP; IDCD; IDPC; PICD; HEL-216; HEL-S-26
-
Reactivity
Human,Mouse,Rat
-
Application
WB, IHC-P, FC, IP
-
Recommended dilution
WB: 1:1000
IHC-P: 1:200-1:1000
FC: 1:20-1:50
IP: 1:20-1:50
-
Calculated MW
47 kDa
-
Observed MW
47 kDa
-
Host species
Rabbit
-
Clonality
Monoclonal
-
Clonality No.
DGR15229
-
Isotype
IgG
-
Purity
Affinity Purification
-
Conjugation
Un-conjugated
-
Concentration
1 mg/ml
-
Formulation
PBS Only
-
Storage/Stability
Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
订购信息
-
Package
Price (RMB)
-
100μg
4498
- 货期：现货
For research use only. Not intended for diagnostic.
浙公网安备 33010602008812号