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RPA32/RPA2 (DGR15080) Rabbit mAb
db11362
Datasheet
- Background This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017]
- Immunogen A synthetic peptide of human RPA32/RPA2
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Gene ID
6118
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Swiss Prot
P15927
- Synonyms REPA2; RPA32; RP-A p32; RP-A p34
- Reactivity Human, Rat
- Application WB, IHC
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Recommended dilution
WB: 1:1000-1:5000
IHC: 1:50-1:500 - Calculated MW 29 kDa
- Observed MW 29 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR15080
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of RPA32/RPA2 in K562,C6 cell lysates using RPA32/RPA2 antibody(1:1000 diluted). -
Immunohistochemical analysis of paraffin-embedded human tonsil using db11362 antibody.
订购信息
- Package Price (RMB)
- 10μL 398
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
