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pro Caspase-1 (DGR14133) Rabbit mAb (PBS Only)
db11405-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
- Immunogen Recombinant protein of human pro Caspase-1
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Gene ID
834
12362
25166
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Swiss Prot
P29466
P29452
P43527
- Synonyms ICE; P45; IL1BC
- Reactivity Human,Mouse,Rat
- Application WB, IP
- Calculated MW 45 kDa
- Observed MW 48,12 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR14133
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/mL
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot analysis of extracts from HeLa cells using db11405 at 1:1000.
订购信息
- Package Price (RMB)
- 100μg 4498
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
