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Conjugation/Formulation：Un-conjugated
- Background The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012]
- Immunogen A synthetic peptide of human DDB1
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Gene ID
1642
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Swiss Prot
Q16531
- Synonyms XPE; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1
- Reactivity Human,Mouse,Rat
- Application WB, IHC-P, ICC/IF
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Recommended dilution
WB: 1:5000-1:50000
IHC-P: 1:100-1:200
ICC/IF: 1:100 - Calculated MW 127 kDa
- Observed MW 127 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR31312
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot analysis of extracts from HeLa, MCF-7, HepG2, U-2 OS, U251, HL-60 cells using db11425 at 1:1000. -
Immunohistochemical analysis of paraffin-embedded human lung cancer using db11425 antibody. -
Immunofluorescent analysis of HeLa cells using db11425 antibody (green), and DAPI (blue). -
Western blot analysis of extracts from PC-12 cells using db11425 at 1:1000.
订购信息
- Package Price (RMB)
- 10μL 398
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
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For research use only. Not intended for diagnostic.
