CDT2单克隆抗体(DGR14659) | 高特异性&高亲和力

产品中心 Products Center

您当前的位置：

Recombinant DGRmAb^®

CDT2 (DGR14659) Rabbit mAb (PBS Only)

db11733-PBS

Datasheet

Product Name : CDT2 (DGR14659) Rabbit mAb (PBS Only)

Cat.No.: db11733-PBS

Synonyms : CDT2; RAMP; DCAF2; L2DTL

Application：

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Un-conjugated PBS Only

Background Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBXO18/FBH1 and KMT5A (PubMed:16861906, PubMed:16949367, PubMed:16964240, PubMed:17085480, PubMed:18703516, PubMed:18794347, PubMed:18794348, PubMed:19332548, PubMed:20129063, PubMed:23478441, PubMed:23478445, PubMed:23677613). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906, PubMed:16949367, PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348, PubMed:19332548).
Immunogen Recombinant protein of human CDT2
Gene ID 51514
Swiss Prot Q9NZJ0
Synonyms CDT2; RAMP; DCAF2; L2DTL
Reactivity Human,Mouse,Rat
Application WB, IHC-P, ICC/IF, FC
Recommended dilution WB: 1:2000-1:20000
IHC-P: 1:100
ICC/IF: 1:100
FC: 1:200
Calculated MW 80 kDa
Observed MW 80 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR14659
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Concentration 1 mg/ml
Formulation PBS Only
Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.

订购信息