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Phospho-PKA RII alpha (Ser99) (DGR16499) Rabbit mAb (PBS Only)
db11883-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]
- Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser99 of human PKA R2
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Gene ID
5576
-
Swiss Prot
P13861
- Synonyms PKR2; PRKAR2
- Reactivity Human,Mouse,Rat
- Application WB, IHC-P, ICC/IF
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Recommended dilution
WB: 1:1000
IHC-P: 1:200-1:500
ICC/IF: 1:200-1:500 - Calculated MW 46 kDa
- Observed MW 50 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR16499
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/ml
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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订购信息
- Package Price (RMB)
- 100μg 5798
- 货期：现货
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For research use only. Not intended for diagnostic.
