Factor XIIIa单克隆抗体(DGR11539) | 高特异性&高亲和力

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Recombinant DGRmAb^®

Factor XIIIa (DGR11539) Rabbit mAb (PBS Only)

db11958-PBS

Datasheet

Product Name : Factor XIIIa (DGR11539) Rabbit mAb (PBS Only)

Cat.No.: db11958-PBS

Synonyms : F13A

Application：

WB
IHC-P
ICC/IF
FC

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Conjugation/Formulation：PBS Only

Un-conjugated PBS Only

Background This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
Immunogen Recombinant protein of human Factor XIIIa
Gene ID 2162
Swiss Prot P00488
Synonyms F13A
Reactivity Human,Mouse,Rat
Application WB, IHC-P, ICC/IF, FC
Recommended dilution WB: 1:1000-1:5000
IHC-P: 1:100-1:200
ICC/IF: 1:50-1:100
FC: 1:10-1:100
Calculated MW 83 kDa
Observed MW 83 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR11539
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Concentration 1 mg/ml
Formulation PBS Only
Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.

Western blot detection of Factor XIIIa in Jurkat cell lysates using db11958(1:1000 diluted).
Immunohistochemical analysis of paraffin-embedded human colon cancer using db11958

订购信息

Package Price (RMB)
100μg 5798
货期：现货