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Recombinant DGRmAb®
Ataxin 1 (DGR14428) Rabbit mAb (PBS Only)
db12665-PBS
Datasheet

Product Name : Ataxin 1 (DGR14428) Rabbit mAb (PBS Only)

Cat.No.: db12665-PBS

Synonyms : ATX1; SCA1; D6S504E

Application：

Reactivity : Human

Host species : Rabbit

Conjugation/Formulation：PBS Only

Un-conjugated PBS Only
  • Background The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 40-83 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2016]
  • Immunogen Recombinant protein of human Ataxin 1
  • Gene ID 6310
  • Swiss Prot P54253
  • Synonyms ATX1; SCA1; D6S504E
  • Reactivity Human
  • Application WB, IP
  • Recommended dilution WB: 1:1000-1:5000
    IP: 1:20-1:50
  • Calculated MW 87 kDa
  • Observed MW 105 kDa
  • Host species Rabbit
  • Clonality Monoclonal
  • Clonality No. DGR14428
  • Isotype IgG
  • Purity Affinity Purification
  • Conjugation Un-conjugated
  • Concentration 1 mg/ml
  • Formulation PBS Only
  • Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
×
  • Western blot detection of Ataxin 1 in 3T3 cell lysates using db12665(1:1000 diluted).
  • Western blot analysis of extracts from T24，C2C12 cells using db12665
订购信息
  • Package Price (RMB)
  • 100μg 5798
  • 货期：现货
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For research use only. Not intended for diagnostic.