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c-Kit (DGR20177) Rabbit mAb (PBS Only)
db12817-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]
- Immunogen Recombinant protein of human c-Kit
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Gene ID
3815
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Swiss Prot
P10721
- Synonyms PBT; SCFR; C-Kit; CD117; MASTC
- Reactivity Mouse,Rat
- Application WB, IHC-P
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Recommended dilution
WB: 1:1000
IHC-P: 1:500-1:2000 - Calculated MW 110 kDa
- Observed MW 120-145 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR20177
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/ml
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot analysis of extracts from Mouse brain tissue using db12817
订购信息
- Package Price (RMB)
- 100μg 5798
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
