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Phospho-p130 (Thr986) (DGR11680) Rabbit mAb (PBS Only)
db13112-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
- Immunogen A synthetic phosphopeptide corresponding to residues surrounding Thr986 of human p130
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Gene ID
5934
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Swiss Prot
Q08999
- Synonyms Rb2; P130
- Reactivity Human,Mouse
- Application WB, FC, IP
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Recommended dilution
WB: 1:1000
FC: 1:100-1:200
IP: 1:100 - Calculated MW 128 kDa
- Observed MW 130 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR11680
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/ml
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot detection of Phospho-Rb2 p130 (Thr986) in K562 cell lysates using Phospho-Rb2 p130 (Thr986) antibody(1:1000 diluted). -
Western blot analysis of extracts from C2C12 cells and Mouse muscle tissue using db13112
订购信息
- Package Price (RMB)
- 100μg 4498
- 货期：现货
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For research use only. Not intended for diagnostic.
