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HSD17B1 (DGR15149) Rabbit mAb (PBS Only)
db13121-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
- Immunogen A synthetic peptide of human HSD17B1
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Gene ID
3292
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Swiss Prot
P14061
- Synonyms E2DH; HSD17; EDHB17; EDH17B2; SDR28C1; 17-beta-HSD; 20-alpha-HSD
- Reactivity Human
- Application WB, IHC-P, FC, IP
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Recommended dilution
WB: 1:2000-1:20000
IHC-P: 1:100-1:200
FC: 1:100-1:200
IP: 1:50 - Calculated MW 35 kDa
- Observed MW 35 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR15149
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/ml
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot detection of HSD17B1 in human placenta cell lysates using db13121(1:1000 diluted).
订购信息
- Package Price (RMB)
- 100μg 5798
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
