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WASP/Wiskott-Aldrich syndrome protein (DGR33461) Rabbit mAb (PBS Only)
db13141-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known. [provided by RefSeq, Jul 2008]
- Immunogen A synthetic peptide of human WASP/Wiskott-Aldrich syndrome protein
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Gene ID
7454
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Swiss Prot
P42768
- Synonyms THC; IMD2; SCNX; THC1; WASP; WASPA
- Reactivity Human
- Application WB, ICC/IF, FC
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Recommended dilution
WB: 1:2000-1:20000
ICC/IF: 1:50
FC: 1:20-1:50 - Calculated MW 53 kDa
- Observed MW 60 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR33461
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/ml
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot analysis of extracts fromU937 cells using db13141
订购信息
- Package Price (RMB)
- 100μg 5798
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
