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Ubiquitin Protein Ligase E3A (DGR34020) Rabbit mAb (PBS Only)
db13149-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
- Immunogen Recombinant protein of human UBE3A
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Gene ID
7337
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Swiss Prot
Q05086
- Synonyms AS; ANCR; E6-AP; HPVE6A; EPVE6AP
- Reactivity Human,Mouse,Rat
- Application WB, ICC/IF, FC, IP
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Recommended dilution
WB: 1:1000
ICC/IF: 1:100
FC: 1:20-1:50
IP: 1:20-1:50 - Calculated MW 101 kDa
- Observed MW 101 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR34020
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/ml
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot analysis of extracts from 3T3 cells using db13149
订购信息
- Package Price (RMB)
- 100μg 5798
- 货期：现货
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For research use only. Not intended for diagnostic.
