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Conjugation/Formulation：Un-conjugated
- Background This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]
- Immunogen A synthetic phosphopeptide corresponding to residues surrounding Tyr774 of human CBL
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Gene ID
867
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Swiss Prot
P22681
- Synonyms CBL2; NSLL; C-CBL; RNF55; FRA11B
- Reactivity Human
- Application WB, IHC-P, FC
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Recommended dilution
WB: 1:1000
IHC-P: 1:100
FC: 1:20 - Calculated MW 100 kDa
- Observed MW 120 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR12781
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of Phospho-CBL (Tyr774) in K562,C6,Hela cell lysates using Phospho-CBL (Tyr774) antibody(1:1000 diluted).
订购信息
- Package Price (RMB)
- 10μL 398
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
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For research use only. Not intended for diagnostic.
