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Hamartin (DGR31827) Rabbit mAb (PBS Only)
db13638-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signalling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including Tsc2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis. [provided by RefSeq, Apr 2018]
- Immunogen A synthetic peptide of human Hamartin
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Gene ID
7248
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Swiss Prot
Q92574
- Synonyms LAM; TSC
- Reactivity Human
- Application WB, IHC-P, FC, IP
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Recommended dilution
WB: 1:1000
IHC-P: 1:100-1:200
FC: 1:20
IP: 1:20-1:50 - Calculated MW 130 kDa
- Observed MW 150-170 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR31827
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/ml
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot analysis of extracts from A549 cells using db13638
订购信息
- Package Price (RMB)
- 100μg 5798
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
