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ErbB 3 (DGR20850) Rabbit mAb (PBS Only)
db13639-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
- Immunogen A synthetic peptide of human ErbB 3
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Gene ID
2065
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Swiss Prot
P21860
- Synonyms HER3; FERLK; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3
- Reactivity Human,Mouse
- Application WB, IHC-P, FC
- Calculated MW 148 kDa
- Observed MW 185 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR20850
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/mL
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot detection of ErbB 3 in A549,MCF-7 cell lysates using ErbB 3 antibody(1:1000 diluted).
订购信息
- Package Price (RMB)
- 10μg 1898
- 100μg 5798
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
