Phospho-ATG16L1 (Ser278) (DGR20461) Rabbit mAb (PBS Only)
Product Name :
Phospho-ATG16L1 (Ser278) (DGR20461) Rabbit mAb (PBS Only)
Cat.No.:
db13896-PBS
Synonyms :
WDR30; Apg16l; Atg16l; 1500009K01Rik
Reactivity :
Mouse
Host species :
Rabbit
Conjugation/Formulation：PBS Only
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Background
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:18849966, PubMed:12665549, PubMed:24954904, PubMed:24553140, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (By similarity). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway. Plays a role in regulating morphology and function of Paneth cell.
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser278 of mouse ATG16L1
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Gene ID
77040
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Swiss Prot
Q8C0J2
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Synonyms
WDR30; Apg16l; Atg16l; 1500009K01Rik
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Reactivity
Mouse
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Application
WB
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Calculated MW
68 kDa
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Observed MW
68 kDa
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Host species
Rabbit
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Clonality
Monoclonal
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Clonality No.
DGR20461
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Concentration
1 mg/ml
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Formulation
PBS Only
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Storage/Stability
Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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100μg
5798
- 货期：现货
For research use only. Not intended for diagnostic.
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