Phospho-FADD (Ser194) (DGR16654) Rabbit mAb (PBS Only)
Product Name :
Phospho-FADD (Ser194) (DGR16654) Rabbit mAb (PBS Only)
Cat.No.:
db13926-PBS
Synonyms :
GIG3; MORT1
Reactivity :
Human
Host species :
Rabbit
Conjugation/Formulation：PBS Only
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Background
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser194 of human FADD
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Gene ID
8772
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Swiss Prot
Q13158
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Synonyms
GIG3; MORT1
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Reactivity
Human
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Application
WB, IP
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Calculated MW
23 kDa
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Observed MW
28 kDa
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Host species
Rabbit
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Clonality
Monoclonal
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Clonality No.
DGR16654
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Concentration
1 mg/mL
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Formulation
PBS Only
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Storage/Stability
Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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100μg
4498
- 货期：现货
For research use only. Not intended for diagnostic.
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