Phospho-MLKL (Ser358) (DGR13914) Rabbit mAb (PBS Only)
Product Name :
Phospho-MLKL (Ser358) (DGR13914) Rabbit mAb (PBS Only)
Cat.No.:
db13999-PBS
Synonyms :
hMLKL
Reactivity :
Human
Host species :
Rabbit
Conjugation/Formulation：PBS Only
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Background
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding
Ser358 of human MLKL
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Gene ID
197259
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Swiss Prot
Q8NB16
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Synonyms
hMLKL
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Reactivity
Human
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Application
WB, IHC-P
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Calculated MW
55 kDa
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Observed MW
55 kDa
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Host species
Rabbit
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Clonality
Monoclonal
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Clonality No.
DGR13914
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Concentration
1 mg/mL
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Formulation
PBS Only
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Storage/Stability
Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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100μg
4498
- 货期：现货
For research use only. Not intended for diagnostic.
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