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Phospho-p53 (Ser392) (DGR11144) Rabbit mAb (PBS Only)
db14129-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
- Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser392 of human p53
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Gene ID
7157
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Swiss Prot
P04637
- Synonyms P53; BCC7; LFS1; TRP53
- Reactivity Human
- Application WB, IHC-P
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Recommended dilution
WB: 1:1000-1:5000
IHC-P: 1:100-1:200 - Calculated MW 44 kDa
- Observed MW 53 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR11144
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/ml
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot analysis of extracts from 293 cells using db14129 at 1:1000. -
Western blot analysis of extracts from SW620 cells using db14129 at 1:1000. -
Western blot analysis of extracts from HepG2 cells using db14129 at 1:1000.
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For research use only. Not intended for diagnostic.
