53BP1单克隆抗体(DGR20780) | 高特异性&高亲和力

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Recombinant DGRmAb^®

53BP1 (DGR20780) Rabbit mAb (PBS Only)

db14226-PBS

Datasheet

Product Name : 53BP1 (DGR20780) Rabbit mAb (PBS Only)

Cat.No.: db14226-PBS

Synonyms : TP53; p202; 53BP1; TDRD30; p53BP1

Application：

Reactivity : Human

Host species : Rabbit

Un-conjugated PBS Only

Background This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Immunogen A synthetic peptide of human 53BP1
Gene ID 7158
Swiss Prot Q12888
Synonyms TP53; p202; 53BP1; TDRD30; p53BP1
Reactivity Human
Application WB, IHC-P, ICC/IF
Recommended dilution WB: 1:5000-1:50000
IHC-P: 1:50-1:100
ICC/IF: 1:100-1:200
Calculated MW 214 kDa
Observed MW 450 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR20780
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Concentration 1 mg/ml
Formulation PBS Only
Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.

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