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Product Name : Phospho-Phospholamban (Ser16) (DGR20062) Rabbit mAb
Cat.No.: db14274
Synonyms : PLB; CMD1P; CMH18
Application：
Reactivity : Human, Mouse
Host species : Rabbit
Conjugation/Formulation：Un-conjugated
- Background The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
- Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser16 of human Phospholamban
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Gene ID
5350
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Swiss Prot
P26678
- Synonyms PLB; CMD1P; CMH18
- Reactivity Human,Mouse
- Application WB
- Recommended dilution WB: 1:2000-1:10000
- Calculated MW 6 kDa
- Observed MW 12,24 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR20062
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot analysis of extracts from Mouse heart tissue using db14274 at 1:1000.
订购信息
- Package Price (RMB)
- 10μL 398
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
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For research use only. Not intended for diagnostic.
