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Conjugation/Formulation：Un-conjugated
- Background The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
- Immunogen A synthetic peptide of human p40-phox
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Gene ID
4689
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Swiss Prot
Q15080
- Synonyms NCF; CGD3; P40PHOX; SH3PXD4
- Reactivity Human
- Application WB, IHC-P, ICC/IF, FC, IP
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Recommended dilution
WB: 1:2000-1:20000
IHC-P: 1:100-1:200
ICC/IF: 1:100-1:200
FC: 1:20-1:100
IP: 1:50 - Calculated MW 39 kDa
- Observed MW 40 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR32114
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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Western blot detection of p40-phox in HL-60,U251 cell lysates using p40-phox antibody(1:1000 diluted). -
Immunohistochemical analysis of paraffin-embedded human tonsil using db14387 antibody. -
Immunofluorescent analysis of HeLa cells using db14387 antibody (green), and DAPI (blue).
订购信息
- Package Price (RMB)
- 10μL 398
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
