ULK1 (DGR16797) Rabbit mAb (PBS Only)
Product Name :
ULK1 (DGR16797) Rabbit mAb (PBS Only)
Cat.No.:
db14796-PBS
Synonyms :
ATG1; ATG1A; UNC51; hATG1; Unc51.1
Reactivity :
Human
Host species :
Rabbit
Conjugation/Formulation：PBS Only
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Background
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).
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Immunogen
A synthetic peptide of human ULK1
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Gene ID
8408
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Swiss Prot
O75385
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Synonyms
ATG1; ATG1A; UNC51; hATG1; Unc51.1
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Reactivity
Human
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Application
WB
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Recommended dilution
WB: 1:2000-1:20000
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Calculated MW
113 kDa
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Observed MW
130 kDa
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Host species
Rabbit
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Clonality
Monoclonal
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Clonality No.
DGR16797
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Concentration
1 mg/ml
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Formulation
PBS Only
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Storage/Stability
Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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100μg
5798
- 货期：现货
For research use only. Not intended for diagnostic.
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