您当前的位置：
SHC (DGR16780) Rabbit mAb
db14801
Datasheet
- Background This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- Immunogen A synthetic peptide of human SHC
-
Gene ID
6464
-
Swiss Prot
P29353
- Synonyms SHC; SHCA
- Reactivity Human,Mouse,Rat
- Application WB, IHC-P
-
Recommended dilution
WB: 1:1000
IHC-P: 1:100-1:200 - Calculated MW 63 kDa
- Observed MW 46,52,66 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR16780
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
×
![]()
-
Western blot analysis of extracts from MCF-7，HUVEC cells using db14801 at 1:1000. -
Western blot analysis of extracts from PC-12 cells using db14801 at 1:1000.
订购信息
- Package Price (RMB)
- 10μL 398
- 20μL 698
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
