HEXB单克隆抗体(DGR16641) | 高特异性&高亲和力

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Recombinant DGRmAb^®

HEXB (DGR16641) Rabbit mAb (PBS Only)

db14830-PBS

Datasheet

Product Name : HEXB (DGR16641) Rabbit mAb (PBS Only)

Cat.No.: db14830-PBS

Synonyms : ENC-1AS; HEL-248; HEL-S-111

Application：

Reactivity : Human

Host species : Rabbit

Un-conjugated PBS Only

Background Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Immunogen A synthetic peptide of human HEXB
Gene ID 3074
Swiss Prot P07686
Synonyms ENC-1AS; HEL-248; HEL-S-111
Reactivity Human
Application WB, IHC-P
Recommended dilution WB: 1:1000-1:5000
IHC-P: 1:20-1:200
Calculated MW 63 kDa
Observed MW 63 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR16641
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Concentration 1 mg/ml
Formulation PBS Only
Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.

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