ErbB 2 (DGR16550) Rabbit mAb (PBS Only)
Product Name :
ErbB 2 (DGR16550) Rabbit mAb (PBS Only)
Cat.No.:
db14845-PBS
Synonyms :
NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
Reactivity :
Human
Host species :
Rabbit
Conjugation/Formulation：PBS Only
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Background
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
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Immunogen
Recombinant protein of human ErbB 2
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Gene ID
2064
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Swiss Prot
P04626
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Synonyms
NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
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Reactivity
Human
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Application
IHC-P
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Recommended dilution
IHC-P: 1:100
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Calculated MW
138 kDa
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Host species
Rabbit
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Clonality
Monoclonal
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Clonality No.
DGR16550
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Concentration
1 mg/ml
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Formulation
PBS Only
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Storage/Stability
Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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100μg
4498
- 货期：现货
For research use only. Not intended for diagnostic.
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