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Proteasome Activator Subunit 4 (DGR16232) Rabbit mAb (PBS Only)
db14883-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis.
- Immunogen A synthetic peptide of human Proteasome Activator Subunit 4
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Gene ID
23198
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Swiss Prot
Q14997
- Synonyms PA200
- Reactivity Human,Mouse,Rat
- Application WB, IHC-P
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Recommended dilution
WB: 1:1000
IHC-P: 1:200-1:1000 - Calculated MW 211 kDa
- Observed MW 211 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR16232
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/ml
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot analysis of extracts from HepG2 cells using db14883
订购信息
- Package Price (RMB)
- 100μg 5798
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
