RAG2单克隆抗体(DGR15242) | 高特异性&高亲和力

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Recombinant DGRmAb^®

RAG2 (DGR15242) Rabbit mAb (PBS Only)

db15105-PBS

Datasheet

Product Name : RAG2 (DGR15242) Rabbit mAb (PBS Only)

Cat.No.: db15105-PBS

Synonyms : Rag-2

Application：

Reactivity : Mouse

Host species : Rabbit

Un-conjugated PBS Only

Background Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactions and the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps.
Immunogen A synthetic peptide of mouse RAG2
Gene ID 19374
Swiss Prot P21784
Synonyms Rag-2
Reactivity Mouse
Application WB
Recommended dilution WB: 1:1000-1:5000
Calculated MW 59 kDa
Observed MW 59 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR15242
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Concentration 1 mg/ml
Formulation PBS Only
Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.

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