Factor XIIIa (DGR15076) Rabbit mAb
Product Name :
Factor XIIIa (DGR15076) Rabbit mAb
Cat.No.:
db15151
Synonyms :
F13A
Reactivity :
Human, Mouse
Host species :
Rabbit
Conjugation/Formulation：Un-conjugated
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Background
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
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Immunogen
A synthetic peptide of human Factor XIIIa
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Gene ID
2162
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Swiss Prot
P00488
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Synonyms
F13A
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Reactivity
Human,Mouse
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Application
WB, IHC-P
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Recommended dilution
WB: 1:5000-1:50000
IHC-P: 1:100-1:200
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Calculated MW
83 kDa
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Observed MW
83 kDa
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Host species
Rabbit
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Clonality
Monoclonal
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Clonality No.
DGR15076
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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10μL
398
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20μL
698
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50μL
1398
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100μL
2398
- 货期：现货
For research use only. Not intended for diagnostic.
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